Why choose RenoFlavoneTM

Safety studies were performed by GLP certified laboratories

✔️ Bacterial Reverse Mutation Test

✔️ Mice Erythrocyte Micronucleus

✔️ Acute Oral Toxicity Studies

✔️ Repeated 28-Day Oral Toxicity Study

Health Benefits of Genistein

WOMEN’S HEALTH

Supports Bone Strength

1.Arcoraci, Atteritano, et al., “Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial.” Nutrients, 9(2), 179. (2017) https://doi.org/10.3390/nu9020179

Heart Health

2.Villa, Paola, et al. “The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status.” The Journal of Clinical Endocrinology & Metabolism 94.2 (2009): 552-558. https://doi.org/10.1210/jc.2008-0735

3.Atteritano, Marco, et al. “Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study.” The Journal of Clinical Endocrinology & Metabolism 92.8 (2007): 3068-3075. https://doi.org/10.1210/jc.2006-2295

4.Crisafulli, Alessandra, et al. “Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women.” Menopause 12.2 (2005): 186-192. https://doi.org/10.1097/00042192-200512020-00013

Antiobesity

5.Akhlaghi, Masoumeh, Morteza Zare, and Fatemeh Nouripour. “Effect of soy and soy isoflavones on obesity-related anthropometric measures: a systematic review and meta-analysis of randomized controlled clinical trials.” Advances in Nutrition 8.5 (2017): 705-717. https://doi.org/10.3945/an.117.015370

6.Christie, Daniel R., et al. “Metabolic effects of soy supplementation in postmenopausal Caucasian and African American women: a randomized, placebo-controlled trial.” American journal of obstetrics and gynecology 203.2 (2010): 153-e1. http://doi.org/10.1016/j.ajog.2010.02.058
Beauty skin

7.Silva, Lidia Aragão, et al. “Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial.” Gynecological Endocrinology 33.11 (2017): 845-848. https://doi.org/10.1080/09513590.2017.1320708

Promotes Comfort

8.Atteritano, M., et al. “Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study.” Osteoporosis international 25.3 (2014): 1123-1129. https://doi.org/10.1007/s00198-013-2512-5

Cognitive health

9.Huang, Mei-Hua, et al. “Dietary genistein intake and cognitive performance in a multiethnic cohort of midlife women.” Menopause 13.4 (2006): 621-630. https://doi.org/10.1097/01.gme.0000227336.35620.8f

Sleep/Relax support

10.Hachul, Helena, et al. “Isoflavones decrease insomnia in postmenopause.” Menopause 18.2 (2011): 178-184. https://doi.org/10.1097/gme.0b013e3181ecf9b9

∮ CARDIOVASCULAR HEALTH

1.Wei, Tzu-Tang, et al. “Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.” Cell 185.10 (2022): 1676-1693. https://doi.org/10.1016/j.cell.2022.04.005

2.Amerizadeh, Atefeh, et al. “Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis.” Current Problems in Cardiology (2021): 100902. https://doi.org/10.1016/j.cpcardiol.2021.100902

∮ METABOLIC HEALTH

1.Squadrito, Francesco, et al. “Genistein in the metabolic syndrome: results of a randomized clinical trial.” The Journal of Clinical Endocrinology & Metabolism 98.8 (2013): 3366-3374. https://doi.org/10.1210/jc.2013-1180

2.Amanat, Sasan, et al. “Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial.” Clinical Nutrition 37.4 (2018): 1210-1215.https://doi.org/10.1016/j.clnu.2017.05.028

∮ HEALTHY AGEING

1.Mas-Bargues, Cristina, Consuelo Borrás, and José Viña. “The multimodal action of genistein in Alzheimer’s and other age-related diseases.” Free Radical Biology and Medicine (2022).https://doi.org/10.1016/j.freeradbiomed.2022.03.021

∮ KIDNEY HEALTH

1.Peng, Qianwen, et al. “Effects of Genistein on Common Kidney Diseases.” Nutrients 14.18 (2022): 3768. https://doi.org/10.3390/nu14183768

∮ BRAIN HEALTH

1.Viña, José, et al. “Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial.” Alzheimer’s Research & Therapy 14.1 (2022): 1-10.https://doi.org/10.1186/s13195-022-01097-2

∮ MICROBIOME MODULATION

1.Aboushanab, Saied A., et al. “Isoflavones derived from plant raw materials: Bioavailability, anti-cancer, anti-aging potentials, and microbiome modulation.” Critical Reviews in Food Science and Nutrition (2021): 1-27. https://doi.org/10.1080/10408398.2021.1946006
2.Guo, Tai L., et al. “Gut microbiome in neuroendocrine and neuroimmune interactions: The case of genistein.” Toxicology and applied pharmacology 402 (2020): 115130. https://doi.org/10.1016/j.taap.2020.115130

∮ SKIN HEALTH

1.Irrera, Natasha, et al. “Dietary management of skin health: The role of genistein.” Nutrients 9.6 (2017): 622. https://doi.org/10.3390/nu9060622

∮ COGNITIVE & BRAIN HEALTH

Memory Health
1.Aranarochana, A., Kaewngam, S., Anosri, T., Sirichoat, A., Pannangrong, W., Wigmore, P., & Welbat, J. U. (2021). Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. Nutrients, 13(12), 4364.https://doi.org/10.3390/nu13124364

2.Moghaddam, A. H., & Zare, M. (2018). Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease. Biomedicine & Pharmacotherapy, 97, 1096-1101.https://doi.org/10.1016/j.biopha.2017.11.047

Neuroprotection

3.Antunes, M. S., Ladd, F. V. L., Ladd, A. A. B. L., Moreira, A. L., Boeira, S. P., & Cattelan Souza, L. (2021). Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis. Metabolic Brain Disease, 36(1), 153-167.https://doi.org/10.1007/s11011-020-00618-y

4.Khan, A., Ikram, M., Hahm, J. R., & Kim, M. O. (2020). Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders. Antioxidants, 9(7), 609.https://doi.org/10.3390/antiox9070609

Why choose RenoFlavoneTM

✔️ Bacterial Reverse Mutation Test

✔️ Mice Erythrocyte Micronucleus

✔️ Acute Oral Toxicity Studies

✔️ Repeated 28-Day Oral Toxicity Study

Health Benefits of Genistein

WOMEN’S HEALTH

Supports Bone Strength
1.Arcoraci, Atteritano, et al., “Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial.” Nutrients, 9(2), 179. (2017) https://doi.org/10.3390/nu9020179
Heart Health
2.Villa, Paola, et al. “The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status.” The Journal of Clinical Endocrinology & Metabolism 94.2 (2009): 552-558. https://doi.org/10.1210/jc.2008-0735
3.Atteritano, Marco, et al. “Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study.” The Journal of Clinical Endocrinology & Metabolism 92.8 (2007): 3068-3075. https://doi.org/10.1210/jc.2006-2295
4.Crisafulli, Alessandra, et al. “Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women.” Menopause 12.2 (2005): 186-192. https://doi.org/10.1097/00042192-200512020-00013
Antiobesity
5.Akhlaghi, Masoumeh, Morteza Zare, and Fatemeh Nouripour. “Effect of soy and soy isoflavones on obesity-related anthropometric measures: a systematic review and meta-analysis of randomized controlled clinical trials.” Advances in Nutrition 8.5 (2017): 705-717. https://doi.org/10.3945/an.117.015370
6.Christie, Daniel R., et al. “Metabolic effects of soy supplementation in postmenopausal Caucasian and African American women: a randomized, placebo-controlled trial.” American journal of obstetrics and gynecology 203.2 (2010): 153-e1. http://doi.org/10.1016/j.ajog.2010.02.058
Beauty skin
7.Silva, Lidia Aragão, et al. “Collagen concentration on the facial skin of postmenopausal women after topical treatment with estradiol and genistein: a randomized double-blind controlled trial.” Gynecological Endocrinology 33.11 (2017): 845-848. https://doi.org/10.1080/09513590.2017.1320708
Promotes Comfort
8.Atteritano, M., et al. “Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study.” Osteoporosis international 25.3 (2014): 1123-1129. https://doi.org/10.1007/s00198-013-2512-5
Cognitive health
9.Huang, Mei-Hua, et al. “Dietary genistein intake and cognitive performance in a multiethnic cohort of midlife women.” Menopause 13.4 (2006): 621-630. https://doi.org/10.1097/01.gme.0000227336.35620.8f
Sleep/Relax support
10.Hachul, Helena, et al. “Isoflavones decrease insomnia in postmenopause.” Menopause 18.2 (2011): 178-184. https://doi.org/10.1097/gme.0b013e3181ecf9b9

 

CARDIOVASCULAR HEALTH
1.Wei, Tzu-Tang, et al. “Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.” Cell 185.10 (2022): 1676-1693. https://doi.org/10.1016/j.cell.2022.04.005
2.Amerizadeh, Atefeh, et al. “Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis.” Current Problems in Cardiology (2021): 100902. https://doi.org/10.1016/j.cpcardiol.2021.100902

METABOLIC HEALTH
1.Squadrito, Francesco, et al. “Genistein in the metabolic syndrome: results of a randomized clinical trial.” The Journal of Clinical Endocrinology & Metabolism 98.8 (2013): 3366-3374. https://doi.org/10.1210/jc.2013-1180
2.Amanat, Sasan, et al. “Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial.” Clinical Nutrition 37.4 (2018): 1210-1215.https://doi.org/10.1016/j.clnu.2017.05.028

 

HEALTHY AGEING
1.Mas-Bargues, Cristina, Consuelo Borrás, and José Viña. “The multimodal action of genistein in Alzheimer’s and other age-related diseases.” Free Radical Biology and Medicine (2022).https://doi.org/10.1016/j.freeradbiomed.2022.03.021

 

KIDNEY HEALTH
1.Peng, Qianwen, et al. “Effects of Genistein on Common Kidney Diseases.” Nutrients 14.18 (2022): 3768. https://doi.org/10.3390/nu14183768

 

BRAIN HEALTH
1.Viña, José, et al. “Genistein effect on cognition in prodromal Alzheimer’s disease patients. The GENIAL clinical trial.” Alzheimer’s Research & Therapy 14.1 (2022): 1-10.https://doi.org/10.1186/s13195-022-01097-2

 

MICROBIOME MODULATION
1.Aboushanab, Saied A., et al. “Isoflavones derived from plant raw materials: Bioavailability, anti-cancer, anti-aging potentials, and microbiome modulation.” Critical Reviews in Food Science and Nutrition (2021): 1-27. https://doi.org/10.1080/10408398.2021.1946006
2.Guo, Tai L., et al. “Gut microbiome in neuroendocrine and neuroimmune interactions: The case of genistein.” Toxicology and applied pharmacology 402 (2020): 115130.

https://doi.org/10.1016/j.taap.2020.115130

 

SKIN HEALTH
1.Irrera, Natasha, et al. “Dietary management of skin health: The role of genistein.” Nutrients 9.6 (2017): 622.https://doi.org/10.3390/nu9060622

 

COGNITIVE & BRAIN HEALTH
Memory Health
1.Aranarochana, A., Kaewngam, S., Anosri, T., Sirichoat, A., Pannangrong, W., Wigmore, P., & Welbat, J. U. (2021). Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. Nutrients, 13(12), 4364.https://doi.org/10.3390/nu13124364
2.Moghaddam, A. H., & Zare, M. (2018). Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease. Biomedicine & Pharmacotherapy, 97, 1096-1101.https://doi.org/10.1016/j.biopha.2017.11.047
Neuroprotection
3.Antunes, M. S., Ladd, F. V. L., Ladd, A. A. B. L., Moreira, A. L., Boeira, S. P., & Cattelan Souza, L. (2021). Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis. Metabolic Brain Disease, 36(1), 153-167.https://doi.org/10.1007/s11011-020-00618-y
4.Khan, A., Ikram, M., Hahm, J. R., & Kim, M. O. (2020). Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders. Antioxidants, 9(7), 609.https://doi.org/10.3390/antiox9070609